LCdr. William D. Brown, USN, 4 June 1942–26 January 1943.
LCdr. Andrew J. Hill, USN, 26 January 1943–10 December 1943.
Comdr. Robert Taylor Scott Keith, USN, 10 December 1943–6 February 1945.
Comdr. Dennis C. Lyndon, USN, 6 February 1945–22 December 1945.
Comdr. Arthur G. Hamilton, Jr., USN, 22 December 1945–22 April 1946.
Comdr. Harry C. Mason, USN, 19 February 1951–24 March 1952.
Comdr. Joseph C. Eliot, USN, 24 March 1952–14 June 1955.
Comdr. John B. Kaye, USN, 14 June 1955–29 June 1957.
Comdr. Robert E. Hawthorne, USN, 29 June 1957–14 January 1959.
Comdr. Edmond L. Kelley, USN, 14 January 1959–28 May 1960.
LCdr. David G. Foxwell, USN, 28 May 1960–25 June 1960.
Comdr. Ralph A. Hilson, USN, 25 June 1960–5 April 1962.
Comdr. David E. Cummins, USN, 5 April 1962–18 January 1964.
Comdr. Robert C. Newcomb, USN, 18 January 1964–25 September 1965.
Comdr. William B. Hooffstetter, USN, 25 September 1965–3 August 1967.
Comdr. John M. Henson, USN, 3 August 1967–23 July 1969.
Comdr. John B. Hurd, USN, 23 July 1969–30 January 1970.
LCdr. William D. Brown, USN,
’ first commanding officer. The Browns were known as gracious hosts for social events among officers of the Nicholas
and sister ships under construction at Bath, Maine. In 1949–50, then-Captain Brown commanded battleship Missouri
, unfortunately running her aground in Chesapeake Bay. He retired as Rear Admiral.
Capt. Francis X. McInerney, USN,
was the first commander of Destroyer Squadron 21, and flew his flag in Nicholas
during the major night surface actions in the Solomon Islands in 1943. In his endorsement to Lcdr. Hill’s Action Report following the Battle of Kula Gulf, he wrote, “It is considered that the Nicholas
is deserving of the Presidential Unit Citation for outstanding performance in action.”