Commissioned on 14 February 1942, Juneau initially served in the Atlantic but was transferred to the Pacific in August. Late in October, she took part in the Battle of the Santa Cruz Islands and, on 12 November, fought in the fierce night battle off Guadalcanal. In that action, a torpedo severely damaged the ship. The following morning, the crippled cruiser, down by the bow and struggling to make 18 knots, retired from the battle area. Handling sluggishly as she limped through the glassy-calm sea, Juneau presented a tempting target for Japanese submarine I-26 which lurked nearby. One torpedo, or possibly two, hit the damaged cruiser forward and detonated her magazines. The resulting violent explosion tore the ship apart, and she went down in just 42 seconds.
Four of the brothers—Coxswain Francis Sullivan and Seamen 2d Class Joseph, Madison, and Albert—failed to make it topside in time to abandon their doomed ship. Gunner’s Mate 2d Class George Sullivan, wounded during the 12 November night action, managed to get over the side and pull himself onto a raft, but died of his wounds a few hours later. Only 10 of the approximately 140 men thought to have survived the immediate sinking were rescued.
The Sullivans’ surviving sister Genevieve enlisted in the U.S. Naval Reserve as a Specialist (Recruiter) 3d Class, and, along with her parents Mr. and Mrs. Thomas F. Sullivan, visited over 200 shipyards and manufacturing plants to encourage the workers there.