Attached to Destroyer Squadron 21 in October 1943 as a replacement for Strong, Hopewell participated in the invasion of the Marshall Islands in early 1944 before continuing on to the Solomon Islands in March. From then until October, she supported landings in New Guinea and then served in the Philippines campaign, fighting fought off kamikaze attacks en route to the Lingayen Gulf landings in January 1945.

Operating with her squadon off Corregidor Island at the mouth of Manila Bay, Hopewell was hit by four 6-inch rounds from shore batteries on 14 February (the same day that La Vallette and Radford were mined in nearby Mariveles Harbor). Seventeen members of the crew were killed. After a delayed return to Mare Island Navy Yard for repairs, she completed training in Hawaii and was at Guam when the war ended. She earned nine service stars on her Asiatic-Pacific campaign ribbon during World War II.

Decommissioned in 1947, Hopewell was placed in reserve but was recommissioned in 1951 at San Diego. During the Korean War, she screened carriers of Task Force 77 as their planes attacked communist positions. She also bombarded Wonsan and served on the critical Formosa Patrol. Through a second tour off Korea, she trained Nationalist Chinese sailors and repeated her bombardment of Wonsan, earning four more stars.

In the fifties and sixties, Hopewell continued deployments to the Far East and eventually operated off Vietnam before she was stricken 2 January 1970. She was sunk as a target 11 February 1972.