As a 1,630-tonner authorized in 1938, known at the time to shipmates as a Livermore-class ship, the specifications for Meredith reflected the characteristics of all Gleaves-class ships built at Charleston Navy Yard:
Grayson data plate
    Length Overall: 348' 3"
    Extreme Beam: 36' 3"
    Normal Displacement: 1,630 long tons
    Draft: Mean: 13' 5"
    Designed Complement: Officers, 11; Enlisted, 201
    Designed Shaft Horsepower: 51,000
    Designed Speed: 35 knots
    Screws: Two
    Rudder: One
    Stacks: Two
As commissioned, Grayson’s armament was typical for a mid-1941 Livermore-class destroyer armed as follows:.
DATA

Name: United States Ship Grayson
Type: Destroyer
Namesake: Rear Admiral Cary Travers Grayson
Navy Classification: DD 433
Class: DD 423, Gleaves, also Livermore
Builder: Charleston Navy Yard
Authorized: 23 July 1938
Keel laid: 17 July 1939
Launched: 7 August 1940
Commissioned: 14 February 1941
Decommissioned: 4 February 1947
Scrapped: 1971

    Primary: 5 x 5-inch/38 cal. in five single mounts, gunhouses on Nos. 1, 2 and 5.
    Short-range anti-aircraft: 6 x 0.50 cal. machine guns
    Torpedo Tubes: 10 x 21-inch in two quintuple mount
    ASW: 2 racks for 600-lb. charges; 4 “K”-guns for 300-lb. charges
Her electronics were typical of the period just before SG (surface search) radar became available:
    Radar: SC (air search) and Mk 37 (fire control)
    Sonar: QC
In common with other destroyers of DesDiv 22, her No. 3 5-inch gun was removed to reduce topweight and 20mm single Oerlikon replaced her 0.50 cal. machine guns as follows:
    Primary: 4 x 5-inch/38 cal. in four single mounts
    Short-range anti-aircraft: 6 x 20mm single Oerlikon
    Torpedo Tubes: 10 x 21-inch in two quintuple mount
    ASW: 2 racks for 600-lb. charges; 4 “K”-guns for 300-lb. charges