Smith was attached to the Atlantic Torpedo Fleet upon commissioning and, after three years of active service, was placed in reserve in October 1912. Reactivated with reduced complements in December 1915 for neutrality patrol duty off Boston, Smith arrived in New Orleans on 10 December 1916 for recruiting duty with the Naval Auxiliary Reserve. She arrived at Key West on 12 February 1916 and at New York on 15 February to continue recruiting duty.
With war imminent, Smith was ordered on 1 April 1917 to anchor in the North River to assist the Collector of Customs in preventing the German ships at New York from escaping or destroying themselves. She departed New York on 4 April and operated with the Patrol Force along the east coast from 10 April to 14 May. On 17 April, she reported sighting a submarine which submerged, and then saw a torpedo wake cross her bow; however, neither inflicted damage on the ether. Smith underwent overhaul at the Charleston Navy Yard from 17 May to 16 July, during which time she prepared for distant service.
Smith departed Charleston on 16 July; and, after a stop at Bermuda from 18 to 20 July and three months of patrols in the Azores from 26 July to 5 October, she arrived at Brest, France, on 20 October. For the remainder of the war, Smith escorted eastbound and westbound convoys through the submarine danger area extending about 500 miles to the westward of Brest. Her escort missions were largely uneventful and, despite several sightings of suspected submarines, she made no confirmed kills. She was called upon twice, however, to rescue survivors of torpedoed transports. On 31 May1918, she rescued 240 men from President Lincoln; and, while carrying them into port, unsuccessfully attacked a submarine on 1 June. On 1 July 1918, she rescued survivors from Covington while other destroyers circled the two ships at high speed to deter submarine attack.
Smith underwent repairs in England from 16 September to 3 November 1918 and, after the end of the war, at Brest from 7 March to 2 April 1919. She sailed for the United States on 11 May; and, after arriving at Philadelphia, was decommissioned there on 2 September 1919. She was ordered sold on 28 February 1920 but was withdrawn from sale on 9 June 1920 in response to a request from the Bureau of Construction and Repair for a destroyer, a submarine and a battleship for exhaustive bombing experiments. On 18 September, Smith was anchored in Chesapeake Bay with battleship Indiana and submarine G-1 for the tests, which were completed on 5 November. Smith was then towed back to Philadelphia and, after again being designated a bombing target on 20 July 1921, was sold on 20 December 1921 to James G. Hitner of Philadelphia for scrapping.