Corry conducted special operations with Radio Washington at Annapolis from 18 to 21 May 1942, then sailed 21 May to escort RMS Queen Elizabeth into New York Harbor 22 May. After an escort voyage to Bermuda, she patrolled off Newfoundland between 31 May and 23 June and rejoining her group at Newport 1 July, operated on coastal patrol and escort duty—voyaging several times to Caribbean ports—until 19 October, when she put in to Bermuda. During this period she picked up survivors of the torpedoed SS Ruty from a life raft off Trinidad.
Corry cleared Bermuda 25 October 1942 for Casablanca to participate in the Moroccan landings in the screen of Ranger (CV 4). She left Casablanca 16 November for Norfolk and Boston, and after overhaul resumed her coastal and Caribbean operations until 13 February 1943, when she sailed on escort duty from Norfolk for North Africa, returning 6 March for operations in the western Atlantic. On 11 August she sailed for Scotland and operated with the British Home Fleet, cruising once to Norway, and twice to Iceland to cover the movement of Russian bound convoys. Returning to Boston 3 December, Corry sailed 24 December for escort duty to New Orleans and Panama.
Similar operations continued until 16 February 1944, when Corry sailed for hunter-killer operations in the Atlantic with TG 21.16, arriving at Casablanca 8 March. She left Casablanca 11 March, and on 16 March joined with Bronstein (DE 189) in attacking the German submarine U-801. When the submarine surfaced, Corry sank her with gunfire and picked up her 47 survivors. Corry arrived at Boston 30 March for overhaul followed by training.
Corry cleared Norfolk 20 April 1944 for Great Britain and the staging of the Normandy invasion. She escorted heavy ships and transports across the channel on 6 June, and headed for San Marcouf Island, her station for fire support. At 0633 she was apparetly hit by shore battery fire, which exploded in her engineering spaces, and all power was lost. She may also have been mined. Within minutes, she had broken amidships and her main deck was under 2 feet of water. The order was given to abandon ship, and her survivors were in the water some 2 hours under constant shelling until rescued by Fitch DD 462), Hobson (DD 464), Butler (DD 636) and PT-199. Of her crew, 6 were dead, 16 missing, and 33 injured.
Corry earned five service stars during World War II.