Each year until 1913, she operated along the East Coast out of Boston from April to December and, from January to April, participated in training and battle exercises out of Guantánamo Bay, Cuba. Although placed in reserve on 5 November 1913, she continued duty with the torpedo fleet. On 20 January 1914, she sailed from Charleston, South Carolina, and reached New Orleans on 2 March after stops at Cape Canaveral, Miami, and Key West, Florida and at Mobile, Alabama. The following day, she joined the newly-created Reserve Torpedo Flotilla, operating in the Gulf of Mexico out of Galveston, Texas.
In June, she returned to the Atlantic seaboard, this time based at Norfolk, and resumed coastal patrols and Caribbean exercises.
Sterett’s complement was reduced on 5 January 1916 and, throughout that spring, she operated almost exclusively in the Caribbean. On 1 June 1916, she was a part of the fleet which landed and supported Marines at Monte Cristi, Dominican Republic to march to Santiago to restore order and to protect lives and property. Soon thereafter, Sterett returned to Norfolk and resumed operations along the East Coast. On 1 January 1917, she entered the Mississippi, stopped at New Orleans, and steamed upriver to Vicksburg. She reentered the gulf and patrolled the Texas coast until she was shifted to Key West on 18 March. From there, the destroyer ranged as far as the Cuban coast.
In April of 1917, the United States entered World War I, and by 9 June, Sterett was in Queenstown, Ireland. Throughout the remainder of the war, she operated from Queenstown to meet convoys and conduct them to either Berehaven, Ireland, or to Devonport, England. At these points, British and French destroyers assumed responsibility for the last leg of the voyage.
On 31 May 1918, a little less than a year after her arrival at Queenstown, Sterett was herding a convoy toward the rendezvous point when she came upon a surfaced U-boat. As Sterett closed, the submarine rapidly submerged. Sterett began dropping depth charges furiously and air bubbles and oil soon appeared on the surface, indicating damage to the German raider. After exhausting her supply of depth charges, Sterett pursued the enemy by the U-boat’s wake of bubbles and trail of oil, hoping to force her to exhaust her batteries and air supply. She continued the pursuit through the night, guided in the darkness only by the fumes of the sub’s leaking oil. Finally, at dawn, the destroyer’s persistence was rewarded. She sighted the U-boat on the surface about 1,000 yards ahead. Sterett sliced through the waves at top speed seeking to ram the submarine; but the U-boat countered by swinging hard to port. Sterett passed within 20 feet of the submarine and, as the U-boat attempted to dive, brought her guns to bear. However, without sufficient time to bracket their adversary, Sterett’s gunners watched helplessly as the submarine slid beneath the surface and escaped. For their dogged determination, the officers and men of Sterett received the commendation of the Commander-in-Chief, Coast of Ireland.
The year 1918 brought with it an all-out effort on the part of the Central Powers to bring the war to a successful conclusion. The German Navy increased the intensity of its submarine operations in order to free Germany from the Allies’ ever-tightening blockade. In response to this thrust, Sterett maintained a grueling schedule of convoy duty—a week or more at sea followed by a day or two in port. One of her new techniques, the use of airborne surveillance, presaged modern hunter-killer antisubmarine warfare.
The Allies prevailed, however, and the Armistice, signed on 11 November 1918, brought an end to Sterett’s strenuous duty. By 3 January 1919, she was back in the United States at Charleston. From there, she moved to Philadelphia where she was decommissioned on 9 December 1919.
On 9 March 1935, after a little more than 15 years of inactivity, Sterett was struck from the Navy list. On 28 June, she was sold for scrapping to M. Black and Co. of Norfolk.